Hypoxia – a low level of oxygen in tissues – is associated with the development of many pathological conditions in the human body. Disruption of energy production in cells is one of the key links in the pathogenesis of common diseases, ischemic heart disease, arterial hypertension and diabetes, age related neurodegenerative diseases, ophthalmopathies and musculoskeletal disorders. Most energy-generating processes in cells are localized in mitochondria, whose functions require a normal concentration of oxygen in the tissue. Hypoxia interrupts the citric acid cycle and ATP synthesis in mitochondria, resulting in a number of negative consequences, from dysfunctions in membrane canals to degradation of cellular structures due to excess free radicals.
Some mitochondrial substrates may have the potential to stabilize the work of individual reactions in the Krebs cycle, thus reducing the negative effects of low oxygen levels in the cells. This effect is used in the development of anti-hypoxic therapy presented in the animation of the visual sciences.
In this version of the animation, all references to the name of the medicine are cut out to avoid violating the prescription drug prescription laws.