New antiviral therapy in warts is successful

24.06.2019 | Bradavice news

Antiviral therapy with digoxin and furosemide can effectively suppress warts on the skin. In the study of 80 subjects, nipples were reduced by sequential treatment, and the viral load was less; side effects were tolerable. Treatment could therefore be an alternative to other treatment options.

So far, for the treatment of warts in u.a. surgical removal, icing or salicylic acid. Another, but seemingly, very effective approach was described by Dutch researchers in the new study. It is based on the inhibition of replication of human papillomavirus (HPV), which is thought to cause warts. Scientists used two drugs, digoxin and furosemide, both preventing entry of potassium into the cell [1], This so-called "Ion Antivirus Therapy" (ICVT) has been described in 2006 as a new approach to the treatment of DNA virus infections [2], In the second study it was safe and effective in treating 12 warts patients [3].

Four weapons

In their new, randomized, double-blind, placebo-controlled Phase II study, the authors sought to support the efficacy and tolerability of therapy. They included 80 volunteers who had at least two nipples of diameter ≥ 3 millimeters and randomly deployed them into four groups. The subjects received either digoxin plus furosemide, digoxin alone, alone furosemide or carrier. 78 subjects applied the gel once daily for more than 35 consecutive days; Only a few cases did not follow the daily schedule of the therapy. The amount of gel used on average per day was highly variable (2.9-118 mg).

Digoxin plus furosemide is the most effective

In all intervention groups, the size of the nipple decreased significantly compared with placebo:

  • Digoxin + furosemide vs. Placebo: – 3.0 mm; 95% CI -4.9 to -1.1; p = 0.002
  • Digoxin vs. Placebo: – 1.9 mm; 95% OFF -3.7 to -0.2; p = 0.03
  • Furosemid vs. Placebo: -2.1 mm; 95% CI -3.8 to -0.4; p = 0.01

Viral load was determined at the beginning and end of the test. At the beginning, 200 out of 219 warts were positive for 23 tested HPV types. Of these, HPV27 was the most common (38%), then HPV57 (26%) and HPV2 (24%). In the group receiving digoxin + furosemide, the HPV load at the end of the study was decreased compared to placebo (-94%, 95% CI -100 to -19, p = 0.03). Wart size reduction is significantly associated with decreasing HPV load.

Side effects were similar in different intervention groups. Nasopharyngitis, headache, and flu-like illnesses are most commonly reported.

The authors conclude that antiviral therapy with digoxin and furosemide can effectively and safely reduce warts. Therapy was well tolerated and sometimes even completely eliminated. In patients with common nipples the effects were somewhat better.

In short, the most important thing

QuestionCan digoxin and furosemide gel effectively fight warts?

Answer: Yes, the nipples were smaller and the viral load was lower, the side effects were tolerable.

which means: Treatment can be an alternative method of treating warts.

limitations: no data