Good fats: The necessity of lipids proven for cell renewal 2

Good fats: The necessity of lipids proven for cell renewal

Good fat. Recycling is also essential in human body cells. Autophagy – a cellular process – breaks down defective and potentially harmful proteins or organelles. This suppresses aging, metabolic disorders and other diseases such as cancer. Tobias Eisenberg and his team at the University of Graz Molecular Bioscience Institute have now shown for the first time that the yeast model is that certain newly produced lipids – i.e., fat molecules – are required for this purification process. The research results are published in the current issue of the Journal of Biological Chemistry.

Good fat

In their experiments, the researchers took a rate-limiting step in the production of fatty acids in the body: the so-called acetyl-CoA carboxylase (Accl). Yeasts that were unable to produce lipids on their own due to Accl inhibition showed impaired autophagy and significantly increased mortality during aging. Accl ​​activation, on the other hand, promoted autophagic cell aging ability. "This is an important aspect of our knowledge of this recycling process and puts lipogenesis, that is, the formation of new lipids, in a new light," Eisenberg summarizes.

Scientists speculate that their findings could also be relevant to metabolic disorders. The exact relationships should be explained in further studies on appropriate disease models.

Post:
Gross, Zimmermann, Pendl et al .: Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK, Journal of Biological Chemistry
Doi: 10.1074 / jbc.RA118.007020

Scientific contact:
Ass.-prof. Dr. Tobias Eisenberg
tobias.eisenberg@uni-graz.at
+43 316 380 1499

Original issues:
Gross, Zimmermann, Pendl et al .: Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK, Journal of Biological Chemistry
Doi: 10.1074 / jbc.RA118.007020

idw 2019/08