The new approach makes antibiotics more effective and thus kills antibiotic-resistant bacteria. So now he has clearly been able to find an effective method to fight antibiotic-resistant bacteria.
Antibiotic-resistant bacteria are a major threat
In a recent study from the University of North Carolina, scientists found that using certain molecules makes certain antibiotics effective against Staphylococcus aureus hundreds of times more effective. The results of the investigation were presented in the English journal "Cell Chemical Biology".
Antibiotics are drugs for the prevention and treatment of bacterial infections. However, when bacteria change in response to these drugs, they become resistant. This will make it difficult for them to handle. However, there are currently more and more antibiotic-resistant bacteria and thus more and more life-threatening infections. Methicillin-resistant Staphylococcus areus (MRSA) is one of the deadliest pathogens of today. A resistant type of bacteria, which often infects patients in healthcare, can lead to death.
Previous treatment options
At present, there is an immense need for new ways to fight the bacteria against which standard antibiotics are already powerless. Changes in the permeability of the membrane to induce aminoglycoside uptake are a very effective way to combat Staphylococcus areus, the researchers say. The so-called ramnolipids release the outer membranes of the bacteria so that the aminoglycoside molecules can penetrate better. This new procedure could save many people with so-called super pathogens in the future. It is incurable and therefore often causes serious complications.
Prior treatments often can do nothing against the bacteria of Staphylococcus strains. There are two reasons for this: antibiotic resistance on the one hand and low sensitivity on the other. Bacteria can control their metabolism so that they can survive even in regions with low oxygen, such as lung cystic fibrosis filled with mucus. As a result, the bacteria adapt to their environment and make the outer wall or membrane impermeable to aminoglycoside antibiotics. However, scientists have now discovered that ranolipids can increase the potency of tobramycin against bacteria.
Ramnolipid supplementation is key
In several experiments, the research team tested ramnolipid-tobramycin combinations against Staphylococcus aureus. Bacteria struggled with typical procedures. However, ramnolipids have improved the efficacy of tobramycin against Staphylococcus aureus, MRSA, tobramycin resistant Staphylococcus aureus strains, cystic fibrosis patient strains, and several antibiotic resistant strains. Previously ineffective doses of tobramycin with ranolipids were finally able to quickly kill the bacterial population. They were able to release external bacterial membranes so antibiotics could penetrate quickly and easily. The researchers tested several antibiotics, including tobramycin, amikacin, gentamicin and kanamycin, all of which respond better to ranolipids – including other types of bacteria, such as Clostridium difficile.
Due to the diverse interactions between bacteria, which may affect antibiotic efficacy, further research is needed to improve existing drugs and slow the development of antibiotic resistance. The new method looks promising and an important step in the fight against antibiotic resistance.