September 13th World Sepsis Day should help raise awareness about sepsis to facilitate the early detection of this serious condition.
In Europe, about half a million people suffer from sepsis annually, which is still one of the leading causes of death in the world. September 13 World Sepsis Day should help raise awareness about sepsis to promote the early detection of this serious condition.
When infections in the body get out of control, it is called sepsis – falsely known as blood poisoning. Older people are especially at risk, but also children under the age of one year or people with chronic illnesses. It is triggered by bacteria, viruses or fungi and their toxins and is one of the most aggressive versions of the infection. The causes may be, for example, wound and urinary tract infections, pneumonia, peritonitis, or influenza.
In an attempt to fight the infection, there is an overreaction of the body. Thus, the patient is less threatened by a bacterial attack than by the body's own reaction to this attack. "Host immune dysfunction occurs," said Innsbruck Intensive Care Doctor Michael Joannidis, head of the Joint Institution for Internal Emergency and Intensive Care at the Innsbruck University of Medicine. Once sepsis has arrived, time is the deciding factor: rapid detection of high-risk patients with sepsis outside the intensive care unit is achieved quick couch result It consists of three simple clinical criteria – respiratory rate of 22 / min or greater, blurring of consciousness and systolic blood pressure of less than 100 mm Hg. If at least two of these criteria are met, the likelihood of severe sepsis is increased.
Timely treatment with the right antibiotics is the cornerstone of successful sepsis therapy. Therefore, if sepsis is suspected, the ICU sends blood or urine to the microbiology laboratory as soon as possible. In more severe cases or later the diagnosis of sepsis leads to organ failure and intensive care is required. The organ most commonly affected is the kidney.
"70 percent of patients with sepsis suffer from acute kidney damage," says intensive care physician Michael Joannidis. "We assume that kidney inflammation and lack of oxygen (hypoxia) play an important role." New therapy should focus on these two processes (see JAMA, online publication 24.10.19). Innsbruck Chief Medical Officer Michael Joannidis played a major role in this publication as a Board member and national study coordinator. Current research also at the Innsbruck University of Medicine in the field in the future will provide intensive care patients with better treatment and save on further stress through renal replacement therapy.
A recently published study shows that the "alkaline phosphatase" enzyme with its dual mechanism of action could be a promising candidate for therapy. "Intravenous administration of recombinant alkaline phosphatase over three days did not improve renal function in the first weeks, but after 28 days, as expected," explains Joannidis. In addition, there is an unexpectedly significant effect on patient survival after one or three months. The death rate of these seriously ill patients with intensive care with sepsis and kidney damage decreased by more than 40 percent. In the fall of 2019, the study will begin Phase III, where it is now being conducted in the US and Europe to see if its efficacy and safety can be confirmed. The main focus now is on the effect and side effects and interactions with other medicines.
Source: Innsbruck Medical University