Breast cancer is the most common cancer in women. Scientists at Purdue University and the French Institute de Cancérologie de l'Ouest (ICO) have found that glyphosate, a major ingredient in some common herbicides and pesticides, can lead to breast cancer under certain conditions. The new study comes at a time when it has become known that the next glyphosate process in the US is being delayed. After three courts sentenced BayerMonsanto in the first instance to millions of fines, they negotiated Bayer negotiates with more than 18,000 prosecutors over an out-of-court settlement. The new study is worrying because, according to scientists, it is not a common type of breast cancer, but a more aggressive form that occurs in younger women, also known as luminal B-cancer.
Glyphosate and breast cancer
Glyphosate, in combination with another risk factor, can trigger aggressive breast cancer. A recently published study is further evidence of the widespread evidence for the carcinogenic potential of weed killer glyphosate. Glyphosate herbicides such as Roundup are used in over 85% of genetically modified crops.
No cancer glyphosate – insists on the chemical company Bayer. Bayer acquired US-based seed and glyphosate manufacturing company Monsanto in 2018 for $ 63 billion, and faces an estimated 18,400 claims for giphosathaltiger killer cancer. They went to court because allegedly a Roundup weed killer causes cancer.
While Bayer is seeking a settlement with more than 18,000 US prosecutors, the following lawsuit follows and Australia is added. Gardener Michael Ogalirolo, 54, who was diagnosed with non-Hodgkin's lymphoma after more than 20 years of using Monsanto's examination, has filed a lawsuit against Monsanto from Bayer AG, claiming his illness was due to glyphosate. The Cancer Council in Australia is concerned that there has been no independent or formal review of the chemical glyphosate – a drug in Roundup for more than two decades. Check out a lawsuit against BayerMonsant for non-Hodgkin's lymphoma in Australia! – The first anti-mare lawsuit filed in Australia
Aggressive form of cancer due to glyphosate
Scientists at Purdue University and the French Institute de Cancérologie de l'Ouest (ICO) have found that glyphosate, a major ingredient in some common herbicides and pesticides, can lead to breast cancer under certain conditions. The discovery is another step forward in determining the development of cancer and how it can be prevented.
Scientists know breast cancer prevention will not be easy, but a team of researchers from Purdue University and the National Institute of International Medicine (INSERM) / Institut de Cancérologie de l & # 39; Ouest (ICO) in Nantes, France, say they have recently discovered one of the pieces of the puzzle when it comes to cancer prevention.
Purdue Cancer Research Center, working with the ICO, the Western France Cancer Center, as part of an agreement with Purdue-led Breast Cancer International initiative, has discovered that glyphosate, a major constituent of widely used herbicides. Breast cancer can result in combination with another risk factor. The work was published in Frontiers in Genetics. "This is an important outcome, and no one has shown it before," says Sophie Lelièvre, professor of cancer pharmacology at Purdue College of Veterinary Medicine and co-director of IBCN.
"Evidence that glyphosate can promote tumor growth in combination with other commonly observed risk is an important missing link in determining the cause of cancer." In vitro, non-cancerous human milk epithelial cells of human milk have been used by scientists for a period of 21 days from glyphosate. The cells were then implanted in mice to evaluate tumor formation. Although cells exposed to glyphosate alone did not induce tumor growth, cancerous tumors that developed after glyphosate were combined with molecules associated with oxidative stress. Oxidative stress is a chemical reaction that results from aging, eating, consuming alcohol, smoking, or other stressors, which alters the organization and integrity of the breast genome and supports the development of cancer.
"What particularly worried about tumor growth was that it was not a common type of breast cancer seen in older women," said Lelièvre (…). "It was a more aggressive form that occurs in younger women, also known as luminal B-cancer."
Glyphosate is the subject of widespread scientific debate in cancer research. The U.S. Environmental Protection Agency said in a 2017 risk assessment that the herbicide is unlikely to be carcinogenic. However, in 2015, the International Agency for Research on Cancer at the World Health Organization said glyphosate was "probably carcinogenic". A study published in 2017 also linked glyphosate to non-Hodgkin's lymphoma.
Another important finding was the ability to recognize pathways at the epigenetic level (i.e., chemical markers on DNA and proteins that control gene expression) that glyphosate uses to compromise breast cells. Lelièvre and Gwenola Bougras-Cartron, a senior scientist at the ICO project, hope these findings will allow researchers to identify and reverse the risk of breast cancer associated with this combination of risk factors.
"The big gap is in research that aims to understand why cancer is occurring," Lelièvre said. "This finding is new, mainly because to date there is no scientific evidence that another factor, when associated with common contaminants, is sufficient to develop cancer. It is very difficult to identify what causes breast cancer, but this is a crucial step in the right direction to start. with prevention, as described in the IBCN International Collaboration. (www.purdue.edu/breastcancer) ".
Cancer rates continue to rise worldwide, with breast cancer being the most common form, Cancer.gov said. Lelièvre said these facts alone fuel her motivation for her research, hoping to find a way to prevent cancer before it even begins.
"It was strongly focused on research for both treatment and detection, but prevention is simply not as common," Lelièvre said. "If we can find a way to reduce the risk, we can hope for fewer cases."
The work was funded by the National Cancer League of France (Ligue Nationale Contre le Cancer).
Lelièvre is an advocate for state-of-the-art cell culture models that mimic various stages of cancer development for research, and she has worked with the Purdue research team to develop a device that funds and contributes to the Congressional Breast Cancer Research and Research program. identify risk factors and underlying mechanisms that cause breast cancer. She is also working with researchers to create tumor models in 10 days more appropriate to those in the human body to test new therapies and look for drug sensitivity.
This work fits in with Purdue's giant leap that celebrates global health progress as part of Purdue's 150th anniversary. It is one of four festival themes of the idea of a one-year celebration, designed to present Purdue as an intellectual center for solving real problems.
GMWatch (@GMWatch) October 1, 2019
Pesticides and breast cancer
From Nickel Abbey
Can Herbicides Cause Breast Cancer? Purdue and INSERM scientists have discovered part of the puzzle.
Scientists at Purdue University and the French Cancérologie de l'Ouest Institute (ICO) have discovered that glyphosate, a major ingredient in some widely used herbicides and pesticides, can lead to breast cancer under certain conditions. When it comes to determining how cancer starts and how it can be prevented.
Scientists know the solution has to be found at Purdue University and the Instituto Nacional de Santé et de la Recherche Médicale (INSERM) / Institut de Cancérologie de l & # 39; Ouest (ICO) in Nantes, France, they have just discovered one of the pieces of the puzzle that was missing when it came to cancer prevention.
Purdue Cancer Research Center, working with ICO, Cancer Center of Western France as part of Memorandum of Understanding with Purdue-led Breast Cancer International Initiative, revealed that glyphosate, a major ingredient in widespread herbicides breast cancer combined with another risk factor. The work was published in Frontiers in Genetics.
Said Sophie Lelièvre, Professor of Cancer Pharmacology at Purdue's College of Veterinary Medicine and Co-Chair of IBCN. "Showing that glyphosate can promote tumor growth, in combination with another major risk factor, is a missing link. "
The scientists exposed non-cancerous mammary epithelial cells to glyphosate in vitro for 21 days. The cells were then placed in mice to evaluate tumor formation. Although glyphosate-exposed cells are not associated with oxidative stress. Oxidative stress is the result of aging, eating, consuming alcohol, smoking or other stressors and the aging of the breast genome, helping to develop cancer.
"Lelièvre (pronounced Le-LEE-YEA-va) said," What is particularly alarming about tumor growth? "'It was a more aggressive form found in younger women, known as luminal B cancer."
Glyphosate has been the subject of widespread scientific debate when it comes to cancer research. The U.S. Environmental Protection Agency said in a 2017 risk assessment that the herbicide is unlikely to be carcinogenic. However, in 2015, the International Agency for Research on Cancer at the World Health Organization said glyphosate was "probably carcinogenic." Studies published in 2017, that is, have linked glyphosate to non-Hodgkin's lymphoma.
Another key finding by researchers at the epigenetic level (i.e., chemical labels on DNA and proteins that control gene expression) that glyphosate uses to compromise breast cells. Lelièvre and Gwenola Bougras-Cartron, a leading scientist on the ICO project, hope that this evidence will allow researchers to detect and reverse breast cancer risk if associated with this combination of risk factors.
"Lelièvre said." There is a big gap in research that is developing. "This finding is new, it has not encountered any scientific evidence to show that it has another factor. It is very difficult to determine what causes breast cancer in the international IBCN collaborative work (http://www.purdue.edu/breastcancer). but this is a critical step forward in the right direction. "
Cancer incidence continues to increase globally, with breast cancer being the most common type, according to Cancer.gov. Lelièvre said the facts continue to fuel research for the future.
"It focuses on research for both treatment and detection, but prevention is not widespread," Lelièvre said. "If we can find a way to mitigate the risk, we can hope for fewer cases."
The work was funded by the National Cancer League of France (Ligue National Contre le Cancer).
Lelièvre is a top cell culture researcher who has worked in the field of cancer research at the University of California Breast Cancer Program / Program, which seeks to help identify risk factors and underlying cancer. She is working with researchers to create a tumor model.
This work fits with Purdue's Giant Leaps celebration of the university's global advancement in health as part of Purdue's 150th anniversary. It is one of four themes of the Ideas Festival year-round celebration, designed to portray Purdue as an intellectual center that addresses real issues.
Glyphosate primes mammary cells for tumorigenesis by reprogramming the epigenome in a TET3-dependent manner
Manon Duforestel, Arulaj Nadaradjane, Gwenola Bougras-Cartron, Joséphine Briand, Christophe Olivier, Jean-Sébastien Frenel, François M Vallette, Sophie A. Lelièvre, Pierre-François Cartron
Frontiers in Genetics, September 27, 2019
The Ursula Rissmann-Telle Women's Network
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