A research team from the University of Ulm was able to introduce the so-called beta-amyloidfibrils and from the human brain isolate and then in the lab investigate, These protein fibers are suspected to be Alzheimer's disease trigger. The study, which included researchers from Tübingen, Halle and San Diego, was published in magazine The nature of communication.
Two main causes
Alzheimer's is known to be associated with protein deposits in the brain. Among the researchers, two proteins are considered to be particularly pathogens: tau and beta-amyloid. both of you proteins they form long molecular chains, the so-called fibrils, which then like Fibrous lumps in the brain accumulate. The exact reason why morbidly develops and destroys the brain is not yet known.
Ulm researchers have discovered in their research that fibers isolated from the human brain are clearly different from the synthetically produced fibers used so far for research differentiateOn the one hand, the peptides that make up the fibers are designed differently from the specimens from the test tube. On the other hand, the fibers tested are woven completely different from the synthetic patterns. "This is a significantly different feature that we didn't expect," says Prof. Marcus Fändrich, director of the Institute for Protein Biochemistry at the university.
Samples of three patients
For his study, Fändrich and his team took tissue samples from three patients. The causes of Alzheimer's can be deciphered One step closer Fändrich is convinced. One of the structures that causes the disease is now much more well known.
Great echo in the professional world
"Science will now have to find the conditions in the test tube that cause these structures," Fändrich explains. Based on these beta-amyloid structures, further testing could follow. In addition, it must be proven that the beta-amyloid structure data is for development pharmaceuticals could be used. In the professional world, the latest Ulm news has already sparked a great turnout.
By 2050, three million patients with dementia
incurable According to estimates from the German Alzheimer's Society, about 1.7 million people in Germany suffer from dementia, two-thirds of which are Alzheimer's disease. Each year, about 300,000 new cases occur. By 2050, nearly three million people with dementia are expected as a result of demographic change and an increase in life expectancy across the country. The disease, which has tremendous shrinkage of cells in the brain, is considered incurable.